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Introduction: Refinement of biomarkers and predictors of treatment response could greatly benefit restorative stroke therapeutics. The current study examined the performance of established biomarker/predictor measures in patients undergoing 4 weeks of therapy, and also examined performance of dense array EEG (d-EEG) measures of cortical connectivity.

Methods: Twelve adults (mean age=54.0 ± 16.6 years) with chronic stroke and hemiparesis (Fugl-Meyer (FM) score=39 ± 12, range 23-56, max 66) underwent a baseline 3 minute resting dEEG recording (256 leads) as well as a 3T MRI scan, then received 4 weeks of telerehabilitation therapy. For dEEG measurement of cortical connectivity, mean coherence was derived for the high beta (20-30 Hz) frequency band, then partial least squares (PLS) regression was used to relate resting-state mean beta coherence to: (1) baseline impairment (FM score), and (2 …