作者
Jessica S Little, Roman M Shapiro, Muneerah M Aleissa, Austin Kim, Jun Bai Park Chang, David W Kubiak, Guohai Zhou, Joseph H Antin, John Koreth, Sarah Nikiforow, Corey S Cutler, Rizwan Romee, Nicolas C Issa, Vincent T Ho, Mahasweta Gooptu, Robert J Soiffer, Lindsey R Baden
发表日期
2022/8/1
期刊
Transplantation and cellular therapy
卷号
28
期号
8
页码范围
508. e1-508. e8
出版商
Elsevier
简介
The use of haploidentical donor hematopoietic cell transplantation (haploHCT) has expanded, but recent reports raise concern for increased rates of infectious complications. The incidence and risk factors for invasive fungal disease (IFD) after haploHCT have not been well elucidated. This study aimed to evaluate the incidence and risk factors for IFD after haploHCT. The identification of key risk factors will permit targeted prevention measures and may explain elevated risk for other infectious complications after haploHCT. This single-center retrospective study included all adults undergoing haploHCT between May 2011 and May 2021 (n = 205). The 30-day and 1-year cumulative incidences of proven or probable IFD and 1-year nonrelapse mortality (NRM) were assessed. Secondary analyses evaluated risk factors for invasive yeast infection (IYI) using univariate and multivariable Cox regression models. Twenty …
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JS Little, RM Shapiro, MM Aleissa, A Kim, JBP Chang… - Transplantation and cellular therapy, 2022