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To the Editor: Ulceration is the most common complication of infantile hemangiomas. 1 Recent studies suggest that ulceration may arise because of an imbalance between angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), because Ang-2 promotes angiogenesis in the presence of VEGF but causes endothelial cell death in the absence of VEGF. 2 Agents that decrease the production of Ang-2 might promote ulcer healing. Recently, we showed that triphenylmethane dyes including gentian violet and brilliant green are potent inhibitors of nicotinamide adenine dinucleotide phosphate oxidases, which are highly expressed in endothelial cells and downregulate Ang-2 production. 3 Eosin, which is also a triphenylmethane dye, is used in many countries for the treatment of diaper dermatitis and as a topical antibiotic. 4 We tested whether eosin is efficacious in the treatment of ulcerated hemangiomas of …