作者
Laura S Van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir I Aftanas, Jochen Bauer, Bernhard T Baune, Ivan V Brak, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Konstantin V Danilenko, Udo Dannlowski, Verena Enneking, Elena Filimonova, Katharina Förster, Thomas Frodl, Ian H Gotlib, Nynke A Groenewold, Dominik Grotegerd, Mathew A Harris, Sean N Hatton, Emma L Hawkins, Ian B Hickie, Tiffany C Ho, Andreas Jansen, Tilo Kircher, Bonnie Klimes-Dougan, Peter Kochunov, Axel Krug, Jim Lagopoulos, Renick Lee, Tristram A Lett, Meng Li, Frank P MacMaster, Nicholas G Martin, Andrew M McIntosh, Quinn McLellan, Susanne Meinert, Igor Nenadić, Evgeny Osipov, Brenda WJH Penninx, Maria J Portella, Jonathan Repple, Annerine Roos, Matthew D Sacchet, Philipp G Sämann, Knut Schnell, Xueyi Shen, Kang Sim, Dan J Stein, Marie-Jose van Tol, Alexander S Tomyshev, Leonardo Tozzi, Ilya M Veer, Robert Vermeiren, Yolanda Vives-Gilabert, Henrik Walter, Martin Walter, Nic JA van der Wee, Steven JA van der Werff, Melinda Westlund Schreiner, Heather C Whalley, Margaret J Wright, Tony T Yang, Alyssa Zhu, Dick J Veltman, Paul M Thompson, Neda Jahanshad, Lianne Schmaal
发表日期
2020/7
期刊
Molecular psychiatry
卷号
25
期号
7
页码范围
1511-1525
出版商
Nature Publishing Group UK
简介
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen’s d …
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LS Van Velzen, S Kelly, D Isaev, A Aleman, LI Aftanas… - Molecular psychiatry, 2020