作者
Lianne Schmaal, Elena Pozzi, Tiffany C. Ho, Laura S Van Velzen, Ilya M Veer, Nils Opel, Eus JW Van Someren, Laura KM Han, Lybomir Aftanas, André Aleman, Bernhard T Baune, Klaus Berger, Tessa F Blanken, Liliana Capitão, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans, Thomas Frodl, Cynthia HY Fu, Beata Godlewska, Ian H Gotlib, Roberto Goya-Maldonado, Hans J Grabe, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, Boris A Gutman, Geoffrey B Hall, Ben J Harrison, Sean N Hatton, Marco Hermesdorf, Ian B Hickie, Eva Hilland, Benson Irungu, Rune Jonassen, Sinead Kelly, Tilo Kircher, Bonnie Klimes-Dougan, Axel Krug, Nils Inge Landrø, Jim Lagopoulos, Jeanne Leerssen, Meng Li, David EJ Linden, Frank P MacMaster, Andrew M. McIntosh, David MA Mehler, Igor Nenadić, Brenda WJH Penninx, Maria J Portella, Liesbeth Reneman, Miguel E Rentería, Matthew D Sacchet, Philipp G. Sämann, Anouk Schrantee, Kang Sim, Jair C Soares, Dan J Stein, Leonardo Tozzi, Nic JA van Der Wee, Marie-Jose Van Tol, Robert Vermeiren, Yolanda Vives-Gilabert, Henrik Walter, Martin Walter, Heather C Whalley, Katharina Wittfeld, Sarah Whittle, Margaret J Wright, Tony T Yang, Carlos Zarate Jr, Sophia I Thomopoulos, Neda Jahanshad, Paul M Thompson, Dick J Veltman
发表日期
2020/5/29
来源
Translational psychiatry
卷号
10
期号
1
页码范围
172
出版商
Nature Publishing Group UK
简介
A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 …
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L Schmaal, E Pozzi, T C. Ho, LS Van Velzen, IM Veer… - Translational psychiatry, 2020