作者
Reihaneh Ebrahimi, Mohammad Reza Sepand, Seyed Afshin Seyednejad, Ameneh Omidi, Mostafa Akbariani, Maryam Gholami, Omid Sabzevari
发表日期
2019/12
期刊
DARU Journal of Pharmaceutical Sciences
卷号
27
页码范围
721-733
出版商
Springer International Publishing
简介
Background
The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol, possesses hepatoprotective, antioxidant and anti-inflammatory properties.
Objectives
The present study seeks to address the hepatoprotective effects of Ellagic acid (EA) against MTX-mediated oxidative stress (OS) and widen our current knowledge of the underlying molecular mechanisms of MTX toxicity.
Methods
Wistar rats were orally given EA (5 mg/kg and 10 mg/kg) for 10 successive days and at the end of the third day they were administered a single dose of MTX (20 mg/kg i.p).
Results
After performing biochemical analysis, liver enzymes and malondialdehyde were significantly higher in the MTX group, indicating hepatic oxidative damage. MTX-induced OS was further confirmed with observation of events such as reactive oxygen …
学术搜索中的文章
R Ebrahimi, MR Sepand, SA Seyednejad, A Omidi… - DARU Journal of Pharmaceutical Sciences, 2019