作者
Kumar Sharma, Satish RamachandraRao, Gang Qiu, Hitomi Kataoka Usui, Yanqing Zhu, Stephen R Dunn, Raogo Ouedraogo, Kelly Hough, Peter McCue, Lawrence Chan, Bonita Falkner, Barry J Goldstein
发表日期
2008/5/1
期刊
The Journal of clinical investigation
卷号
118
期号
5
页码范围
1645-1656
出版商
American Society for Clinical Investigation
简介
Increased albuminuria is associated with obesity and diabetes and is a risk factor for cardiovascular and renal disease. However, the link between early albuminuria and adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed studies in a cohort of patients at high risk for diabetes and kidney disease as well as in adiponectin-knockout (Ad–/–) mice. Albuminuria had a negative correlation with plasma adiponectin in obese patients, and Ad–/– mice exhibited increased albuminuria and fusion of podocyte foot processes. In cultured podocytes, adiponectin administration was associated with increased activity of AMPK, and both adiponectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evidenced by zona occludens–1 translocation to the membrane. These …
引用总数
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K Sharma, S RamachandraRao, G Qiu, HK Usui, Y Zhu… - The Journal of clinical investigation, 2008