作者
Fuad N Ziyadeh, Brenda B Hoffman, Dong Cheol Han, M Carmen Iglesias-De la Cruz, Soon Won Hong, Motohide Isono, Sheldon Chen, Tracy A McGowan, Kumar Sharma
发表日期
2000/7/5
期刊
Proceedings of the National Academy of Sciences
卷号
97
期号
14
页码范围
8015-8020
出版商
The National Academy of Sciences
简介
Emerging evidence suggests that transforming growth factor-β (TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-β antibody (αT) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy and increased matrix mRNA. To establish that overactivity of the renal TGF-β system mediates the functional and structural changes of the more advanced stages of nephropathy, we tested whether chronic administration of αT prevents renal insufficiency and glomerulosclerosis in the db/db mouse, a model of type 2 diabetes that develops overt nephropathy. Diabetic db/db mice and nondiabetic db/m littermates were treated intraperitoneally with αT or control IgG, 300 μg three times per week for 8 wk. Treatment with αT, but not with IgG, significantly decreased the plasma TGF-β1 concentration without decreasing the …
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