作者
Subodh Verma, Shaun G Goodman, Shamir R Mehta, David A Latter, Marc Ruel, Milan Gupta, Bobby Yanagawa, Mohammed Al-Omran, Nandini Gupta, Hwee Teoh, Jan O Friedrich
发表日期
2015/12
来源
BMC surgery
卷号
15
页码范围
1-15
出版商
BioMed Central
简介
Background
We assessed the effectiveness of dual antiplatelet therapy (DAPT) post elective or urgent (i.e., post acute coronary syndrome [ACS]) coronary artery bypass graft surgery (CABG).
Methods
We systematically searched MEDLINE, EMBASE, and the Cochrane Registry from inception to August 2015. Randomized controlled trials (RCTs) in adults undergoing CABG comparing either dual vs. single antiplatelet therapy or higher- vs. lower-intensity DAPT were identified.
Results
Nine RCTs (n = 4,887) with up to 1y follow-up were included. Five RCTs enrolled patients post-elective CABG (n = 986). Two multi-centre RCTs enrolled ACS patients who subsequently underwent CABG (n = 2,155). These 7 RCTs compared clopidogrel plus aspirin to aspirin alone. Two other multi-centre RCTs reported on ACS …
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S Verma, SG Goodman, SR Mehta, DA Latter, M Ruel… - BMC surgery, 2015