查看文章

Background. Group B coxsackievirus infection can result in organ injury and inflammation. The coxsackievirus and adenovirus receptor (CAR) and decay-accelerating factor (DAF; CD55) have both been identified as receptors for coxsackievirus B3 (CVB3). We have shown elsewhere that early DAF-Fc treatment attenuates CVB3-induced myocarditis and virus replication.

Methods. CAR was synthesized as a soluble IgG1-Fc fusion protein (CAR-Fc). In vitro, CAR-Fc blocked infection by 2 different strains of CVB3. A/J mice were infected in vivo with CVB3 and were administered CARFc either 3 days before infection, during infection, or 3 days after infection and were compared with mice infected with virus alone and control animals.

Results. All CAR-Fc treatment groups had reduced recoverable infectious virus in the heart. CAR-Fc treatment of …