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Previous findings indicate that post-training administration of the anxiogenic α₂-adrenoceptor antagonist RS 79948-197 facilitates the consolidation of dorsal striatal-dependent habit memory. The present study examined the effect of concurrent administration of the anxiolytic serotonin 5-HT_1A receptor partial agonist buspirone on anxiety-induced facilitation of habit memory. Male Long-Evans rats were trained in a response learning version of a water plus-maze task that requires animals to learn to make the same body turn response on each trial in order to reach a hidden escape platform. Immediately following training on days 1–3, rats received peripheral injections of either saline, buspirone (1.5mg/kg, 2.0mg/kg, or 5.0mg/kg), RS 79948-197 (0.1mg/kg), or RS 79948-197 and buspirone together. Post-training injections of RS 79948-197 alone significantly enhanced memory consolidation. The highest dose of …