作者
NE Skakkebaek, JG Berthelsen, A Giwercman, J Müller
发表日期
1987/2
期刊
International journal of andrology
卷号
10
期号
1
页码范围
19-28
出版商
Blackwell Publishing Ltd
简介
Based on evidence from morphological and histochemical studies and from clinical experience, the following hypotheses are proposed: (1) carcinoma‐in‐situ (CIS) germ cells are malignant gonocytes; (2) these CIS gonocytes have some capacity to regress into more primitive, totipotent embryonic cells which can give rise to all types of nonseminomatous germ cell tumours; (3) the tumour germ cells of classical seminomas are malignant gonocytes derived from CIS gonocytes which have lost their ability to regress into totipotent embryonic cells; (4) the ability of CIS gonocytes to regress into totipotent embryonic cells decreases with age, whereas the capacity to form classical seminoma cells is preserved; (5) the transformation of CIS gonocytes into invasive tumours is dependent on factors such as gonadotrophins and/or testicular steroids; (6) the pathogenesis of classical and spermatocytic seminoma are unrelated …
引用总数
学术搜索中的文章
NE Skakkebaek, JG Berthelsen, A Giwercman, J Müller - International journal of andrology, 1987
NE Skakkebæk - Urologic Clinics of North America, 1982