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Although ¹⁸F-labeled NaF was the first widely used agent for skeletal scintigraphy, it quickly fell into disuse after the introduction of ^99mTc-labeled bone-imaging agents. Recent comparative studies have demonstrated that ¹⁸F-fluoride PET is more accurate than ^99mTc-diphosphonate SPECT for identifying both malignant and benign lesions of the skeleton. Combining ¹⁸F-fluoride PET with other imaging, such as CT, can improve the specificity and overall accuracy of skeletal ¹⁸F-fluoride PET and probably will become the routine clinical practice for ¹⁸F-fluoride PET. Although ¹⁸F-labeled NaF and ^99mTc-diphosphonate have a similar patient dosimetry, ¹⁸F-fluoride PET offers shorter study times (typically less than 1 h), resulting in a more efficient workflow, improved patient convenience, and faster turnarounds of reports to the referring physicians. With the widespread availability of PET scanners and the …