作者
NJN Harper, TM Cook, T Garcez, L Farmer, K Floss, S Marinho, H Torevell, A Warner, K Ferguson, J Hitchman, W Egner, H Kemp, M Thomas, DN Lucas, S Nasser, S Karanam, K-L Kong, S Farooque, M Bellamy, N McGuire
发表日期
2018/7/1
期刊
British Journal of Anaesthesia
卷号
121
期号
1
页码范围
159-171
出版商
Elsevier
简介
Background
Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists.
Methods
The 6th National Audit Project (NAP6) on perioperative anaphylaxis collected and reviewed 266 reports of Grades 3–5 anaphylaxis over 1 yr from all NHS hospitals in the UK.
Results
The estimated incidence was ≈1:10 000 anaesthetics. Case exclusion because of reporting delays or incomplete data means true incidence might be ≈70% higher. The distribution of 199 identified culprit agents included antibiotics (94), neuromuscular blocking agents (65), chlorhexidine (18), and Patent Blue dye (9). Teicoplanin comprised 12% of antibiotic exposures, but caused 38% of antibiotic-induced anaphylaxis. Eighteen patients reacted to an antibiotic test dose. Succinylcholine-induced anaphylaxis, mainly presenting with bronchospasm, was two-fold more likely than other neuromuscular blocking agents. Atracurium …
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NJN Harper, TM Cook, T Garcez, L Farmer, K Floss… - British Journal of Anaesthesia, 2018
