作者
Wei-Kung Wang, Hui-Ling Chen, Chao-Fu Yang, Szu-Chia Hsieh, Chung-Chou Juan, Shu-Mei Chang, Cheng-Ching Yu, Li-Hui Lin, Jyh-Hsiung Huang, Chwan-Chuen King
发表日期
2006/10/15
期刊
Clinical Infectious Diseases
卷号
43
期号
8
页码范围
1023-1030
出版商
The University of Chicago Press
简介
Background . Although previous studies have revealed the contribution of an initial high level of dengue virus replication to the severe and potentially life-threatening diseases dengue hemorrhagic fever (DHF) and dengue shock syndrome, the involvement of dengue virus in the immuopathological processes during the transition from fever to defervescence, which is a critical stage in determining the progression to DHF, has not been appreciated. Previously, we reported that dengue virus can be detected in the immune complexes of patients with DHF during this period.
Methods . We investigated plasma dengue viral load, virus in immune complexes, antibody response, complements, and cytokines for 54 patients with dengue fever (a relatively mild form of disease) and 49 patients with DHF. The patients had confirmed secondary infection with dengue virus type 2 from …
引用总数
学术搜索中的文章
WK Wang, HL Chen, CF Yang, SC Hsieh, CC Juan… - Clinical Infectious Diseases, 2006