作者
Alessandro Giardini, Andrea Donti, Roberto Formigari, Salvatore Specchia, Daniela Prandstraller, Gabriele Bronzetti, Marco Bonvicini, Fernando M Picchio
发表日期
2004/5/19
期刊
Journal of the American College of Cardiology
卷号
43
期号
10
页码范围
1886-1891
出版商
American College of Cardiology Foundation
简介
Objectives
We sought to evaluate the course of cardiopulmonary function after transcatheter atrial septal defect (ASD) closure and to identify the physiopathologic mechanisms leading to this change.
Background
Conflicting reports exist on cardiopulmonary functional improvement in asymptomatic adults after transcatheter closure of a secundum ASD.
Methods
Thirty-two consecutive adults (13 males; age 42.6 ± 16.7 years) underwent maximal cardiopulmonary exercise testing and transthoracic echocardiography both on the day before and six months after transcatheter ASD closure. Mean pulmonary artery pressure, pulmonary to systemic flow ratio (Qp/Qs), and ASD diameter were measured before closure.
Results
Peak oxygen uptake (Vo2) (p < 0.001), peak oxygen pulse (p = 0.0027), and vital capacity (p = 0.0086) improved after ASD closure, although peak heart rate did not.A significant correlation was found …
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A Giardini, A Donti, R Formigari, S Specchia… - Journal of the American College of Cardiology, 2004