作者
Sharon Fleischer, Ron Feiner, Assaf Shapira, Jing Ji, Xiaomeng Sui, H Daniel Wagner, Tal Dvir
发表日期
2013/11/1
期刊
Biomaterials
卷号
34
期号
34
页码范围
8599-8606
出版商
Elsevier
简介
Recapitulation of the cellular microenvironment of the heart, which promotes cell contraction, remains a key challenge in cardiac tissue engineering. We report here on our work, where for the first time, a 3-dimensional (3D) spring-like fiber scaffold was fabricated, successfully mimicking the coiled perimysial fibers of the heart. We hypothesized that since in vivo straightening and re-coiling of these fibers allow stretching and contraction of the myocardium in the direction of the cardiomyocytes, such a scaffold can support the assembly of a functional cardiac tissue capable of generating a strong contraction force. In this study, the mechanical properties of both spring-like single fibers and 3D scaffolds composed of them were investigated. The measurements showed that they have increased elasticity and extensibility compared to corresponding straight fibers and straight fiber scaffolds. We have also shown that cardiac …
学术搜索中的文章
S Fleischer, R Feiner, A Shapira, J Ji, X Sui… - Biomaterials, 2013