作者
Michal Shevach, Sharon Fleischer, Assaf Shapira, Tal Dvir
发表日期
2014/10/8
期刊
Nano letters
卷号
14
期号
10
页码范围
5792-5796
出版商
American Chemical Society
简介
Decellularized matrices are valuable scaffolds for engineering functional cardiac patches for treating myocardial infarction. However, the lack of quick and efficient electrical coupling between adjacent cells may jeopardize the success of the treatment. To address this issue, we have deposited gold nanoparticles on fibrous decellularized omental matrices and investigated their morphology, conductivity, and degradation. We have shown that cardiac cells engineered within the hybrid scaffolds exhibited elongated and aligned morphology, massive striation, and organized connexin 43 electrical coupling proteins. Finally, we have shown that the hybrid patches demonstrated superior function as compared to pristine patches, including a stronger contraction force, lower excitation threshold, and faster calcium transients.
学术搜索中的文章
M Shevach, S Fleischer, A Shapira, T Dvir - Nano letters, 2014