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Recent evidence suggests that fluorescein-guided microsurgery facilitates resection of intrinsic and metastatic lesions in the brain. Use of sodium fluorescein for angiography has previously been reported without non-specific diffusion into the adjacent spinal parenchyma. Diagnostic biopsy of spinal cord lesion is often challenging and the localization of such lesions intraoperatively is paramount. We present the first known report of use of sodium fluorescein for localization and diagnostic biopsy of intrinsic spinal cord lesions.

Three patients with spinal cord lesions received fluorescein sodium 10% (Alcon Laboratories INC, Fort Worth, TX, USA) at 3 mg/kg prior to surgical resection. Intraoperative visualization of fluorescence was performed using a Zeiss Pentero (Carl Zeiss AG, Oberkochen, Germany) microscope equipped with a Yellow560 filter or a Leica OH6 (Leice Microsystems, Wetzlar …