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Hyperpolarized (HP) ¹³C MRI has enabled real‐time imaging of specific enzyme‐catalyzed metabolic reactions, but advanced pulse sequences are necessary to capture the dynamic, localized metabolic information. Herein we describe the design, implementation, and testing of a rapid and efficient HP ¹³C pulse sequence strategy on a cryogen‐free simultaneous positron emission tomography/MR molecular imaging platform with compact footprint.

We developed an echo planar spectroscopic imaging pulse sequence incorporating multi‐band spectral–spatial radiofrequency (SSRF) pulses for spatially coregistered excitation of ¹³C metabolites with differential individual flip angles. Excitation profiles were measured in phantoms, and the SSRF‐echo planar spectroscopic imaging sequence was tested in rats in vivo and compared to conventional echo planar spectroscopic imaging. The new …