作者
Grazia Maria Virzì, Sonya Day, Massimo de Cal, Giorgio Vescovo, Claudio Ronco
发表日期
2014/2
来源
Critical Care
卷号
18
页码范围
1-11
出版商
BioMed Central
简介
Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant organ cells and their milieu. Heart performance and kidney function are closely interconnected and communication between these organs occurs through a variety of bidirectional pathways. The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. Acute cardiorenal syndrome (CRS type 1) and …
学术搜索中的文章
GM Virzì, S Day, M de Cal, G Vescovo, C Ronco - Critical Care, 2014