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Areca catechu L. nut is a component of betel quid, the chewing of which is a popular or a cultural tradition in some countries in South East Asia. Areca nut contains bioactive components like alkaloids and tannins which have been demonstrated to elicit inhibitory effects in selected microorganisms. Varying concentrations of Areca catechu L. nut ethanol extract were tested for antimicrobial activity against 0.5 McFarland of mixed-oral flora and eight gram-negative clinical isolates (E. coli, K. pneumonia, P. vulgaris, P. aeruginosa, S. non-typhi, S. flexneri and V. cholera) by agar well diffusion method. All concentrations were shown to inhibit growth in all mixed-oral flora models with zones of inhibition ranging from 7 mm to 18 mm. Susceptible patterns were also seen in all gram-negative clinical isolates with the smallest mean of zones of inhibition seen in Escherichia coli which is 8 mm at 30% concentration and …