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To assess the toxicity of copper nanoparticles (23.5nm) in vivo, LD₅₀, morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17μm) and cupric ions (CuCl₂·2H₂O). The LD₅₀ for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are 413, >5000 and 110mg/kg body weight, respectively. The toxicity classes of nano and ionic copper particles both are class 3 (moderately toxic), and micro-copper is class 5 (practically non-toxic) of Hodge and Sterner Scale. Kidney, liver and spleen are found to be target organs of nano-copper particles. Nanoparticles induce gravely toxicological effects and heavy injuries on kidney, liver and spleen of experimental mice, but micro-copper particles do not, on mass basis. Results indicate a gender dependent feature of nanotoxicity. Several factors such …