作者
Scott E Eggener, Peter T Scardino, Patrick C Walsh, Misop Han, Alan W Partin, Bruce J Trock, Zhaoyong Feng, David P Wood, James A Eastham, Ofer Yossepowitch, Danny M Rabah, Michael W Kattan, Changhong Yu, Eric A Klein, Andrew J Stephenson
发表日期
2011/3
期刊
The Journal of urology
卷号
185
期号
3
页码范围
869-875
出版商
Wolters Kluwer
简介
Purpose
Long-term prostate cancer specific mortality after radical prostatectomy is poorly defined in the era of widespread screening. An understanding of the treated natural history of screen detected cancers and the pathological risk factors for prostate cancer specific mortality are needed for treatment decision making.
Materials and Methods
Using Fine and Gray competing risk regression analysis we modeled clinical and pathological data, and followup information on 11,521 patients treated with radical prostatectomy at a total of 4 academic centers from 1987 to 2005 to predict prostate cancer specific mortality. The model was validated on 12,389 patients treated at a separate institution during the same period. Median followup in the modeling and validation cohorts was 56 and 96 months, respectively.
Results
The overall 15-year prostate cancer specific mortality rate was 7%. Primary and secondary Gleason grade …
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SE Eggener, PT Scardino, PC Walsh, M Han… - The Journal of urology, 2011