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 Purpose: To answer a need to include and measure accurately the impact and burden of epilepsy as outcomes of interventions with affected children, we developed and validated self‐report and parent‐proxy respondent health‐related quality of life (HRQL) instruments for preadolescent children with epilepsy.

Methods: We combined qualitative and quantitative research methods. Items were extracted from focus group discussions involving children with epilepsy and their parents. We created scales formatted with alternative paired options of forced responses and used factor analysis to generate relevant subscales and reduce the number of items. We checked internal consistency, assessed test–retest reliability 10–14 days apart, and documented construct validity.

Results: A sample of 381 children with epilepsy, age 6–15 years, and their parents independently completed a 67‐item questionnaire, from which we …