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Over the past 21 years, while the incidence of colorectal cancer in the US has decreased, disparities in race and ethnicity have increased but no recent evaluation exists of differences in race and ethnicity by location of primary tumors within the colon and rectum among all age groups. Recent literature has shown that there are differences in the rates of colorectal cancer between multiple minority groups; however, many of these studies only compare CRC among White and Black groups. We examined the trends of colorectal cancer incidence by racial/ethnic group and location of the primary tumors within the colon and rectum to describe disparities. This study used SEER*Stat v 8.3.9 Incidence – SEER Research Data, 18 Registries, Nov 2020 Sub (2000-2018) to analyze age-adjusted rates in incidence by race, ethnicity, sex, and site. We examined the sites within the proximal, transverse, and distal colon, as well as …