作者
Kazuhiko Kido, Mikiko Shimizu, Tsuyoshi Shiga, Masayuki Hashiguchi
发表日期
2020/7/1
期刊
The American journal of cardiology
卷号
126
页码范围
23-28
出版商
Excerpta Medica
简介
Highlights
- Direct oral anticoagulants did not increase stroke or systemic embolism event rate.
- Direct oral anticoagulants had lower major bleeding rate than warfarin.
- Direct oral anticoagulants are considered as an option in morbidly obese patients.
- A randomized controlled trial is needed to confirm our meta-analysis results.
The International Society of Thrombosis and Haemostasis recommends warfarin therapy over direct oral anticoagulants (DOACs) in patients with a body mass index> 40 kg/m 2 or weight> 120 kg due to limited clinical data in morbidly obese patients. The aim of the meta-analysis was to compare DOACs with warfarin in morbidly obese patients with atrial fibrillation (AF) and to optimize an anticoagulation therapy in the population. MEDLINE, Embase, Google Scholar, Web of Science, and Cochrane Library database searches for relevant articles through December 23, 2019 were performed. Total 5 …
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K Kido, M Shimizu, T Shiga, M Hashiguchi - The American journal of cardiology, 2020