作者
Rena R Wing, Wei Lang, Thomas A Wadden, Monika Safford, William C Knowler, Alain G Bertoni, James O Hill, Frederick L Brancati, Anne Peters, Lynne Wagenknecht, Look AHEAD Research Group
发表日期
2011/7/1
期刊
Diabetes care
卷号
34
期号
7
页码范围
1481-1486
出版商
American Diabetes Association
简介
OBJECTIVE
Overweight and obese individuals are encouraged to lose 5–10% of their body weight to improve cardiovascular disease (CVD) risk, but data supporting this recommendation are limited, particularly for individuals with type 2 diabetes.
RESEARCH DESIGN AND METHODS
We conducted an observational analysis of participants in the Look AHEAD (Action For Health in Diabetes) study (n = 5,145, 40.5% male, 37% from ethnic/racial minorities) and examined the association between the magnitude of weight loss and changes in CVD risk factors at 1 year and the odds of meeting predefined criteria for clinically significant improvements in risk factors in individuals with type 2 diabetes.
RESULTS
The magnitude of weight loss at 1 year was strongly (P < 0.0001) associated with improvements in glycemia, blood pressure, tryiglycerides, and HDL …
引用总数
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