作者
Dara Petel, Nicholas Winters, Genevieve C Gore, Jesse Papenburg, Marc Beltempo, Jacques Lacroix, Patricia S Fontela
发表日期
2018/12/1
来源
Bmj Open
卷号
8
期号
12
页码范围
e022133
出版商
British Medical Journal Publishing Group
简介
Background and objectives
C-reactive protein (CRP) has been proposed to guide the use of antibiotics. However, study results are controversial regarding the benefits of such a strategy. We synthesised the evidence of CRP-based algorithms on antibiotic treatment initiation and on antibiotic treatment duration in adults, children and neonates, as well as their safety profile.
Design
Systematic review and meta-analysis.
Data sources
MEDLINE, EMBASE, CENTRAL and CINAHL from inception to 20 July 2017.
Eligibility criteria for selecting studies
We included randomised controlled trials (RCTs), non-RCTs and cohort studies (prospective or retrospective) investigating CRP-guided antibiotic use in adults, children and neonates with bacterial infection.
Data extraction and synthesis
Two researchers independently screened all identified studies and retrieved the data. Outcomes were duration of antibiotic use, antibiotic …
学术搜索中的文章
D Petel, N Winters, GC Gore, J Papenburg, M Beltempo… - Bmj Open, 2018