作者
Jan Otto Beitnes, Einar Hopp, Ketil Lunde, Svein Solheim, Harald Arnesen, Jan E Brinchmann, Kolbjørn Forfang, Svend Aakhus
发表日期
2009/12/15
期刊
Heart
卷号
95
期号
24
页码范围
1983-1989
出版商
BMJ Publishing Group Ltd
简介
Objective
To investigate long-term safety and efficacy after intracoronary injection of autologous mononuclear bone marrow cells (mBMCs) in acute myocardial infarction (AMI).
Design
Randomised, controlled trial.
Setting
Two university hospitals in Oslo, Norway.
Patients
Patients from the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) study were re-assessed 3 years after inclusion.
Interventions
100 patients with anterior wall ST-elevation myocardial infarction treated with acute percutaneous coronary intervention (PCI) were randomised to receive intracoronary injection of mBMCs (n = 50) or not (n = 50).
Main outcome measures
Change in left ventricular (LV) ejection fraction (primary). Change in exercise capacity (peak VO2) and quality of life (secondary). Infarct size (additional aim), and safety.
Results
The rates of adverse clinical events in the groups were low and equal. There were …
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JO Beitnes, E Hopp, K Lunde, S Solheim, H Arnesen… - Heart, 2009