作者
Po-Ru Loh, Mark Lipson, Nick Patterson, Priya Moorjani, Joseph K Pickrell, David Reich, Bonnie Berger
发表日期
2013/4/1
期刊
Genetics
卷号
193
期号
4
页码范围
1233-1254
出版商
Oxford University Press
简介
Long-range migrations and the resulting admixtures between populations have been important forces shaping human genetic diversity. Most existing methods for detecting and reconstructing historical admixture events are based on allele frequency divergences or patterns of ancestry segments in chromosomes of admixed individuals. An emerging new approach harnesses the exponential decay of admixture-induced linkage disequilibrium (LD) as a function of genetic distance. Here, we comprehensively develop LD-based inference into a versatile tool for investigating admixture. We present a new weighted LD statistic that can be used to infer mixture proportions as well as dates with fewer constraints on reference populations than previous methods. We define an LD-based three-population test for admixture and identify scenarios in which it can detect admixture events that previous formal tests cannot. We …
引用总数
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学术搜索中的文章
PR Loh, M Lipson, N Patterson, P Moorjani, JK Pickrell… - Preprint at arXiv [online], http://uk. arxiv. org/abs …, 2012