作者
Candelaria Vergara, Tanda Murray, Nicholas Rafaels, Rachel Lewis, Monica Campbell, Cassandra Foster, Li Gao, Mezbah Faruque, Ricardo Riccio Oliveira, Edgar Carvalho, Maria Ilma Araujo, Alvaro A Cruz, Harold Watson, Dilia Mercado, Jennifer Knight‐Madden, Ingo Ruczinski, Georgia Dunston, Jean Ford, Luis Caraballo, Terri H Beaty, Rasika A Mathias, Kathleen C Barnes
发表日期
2013/5/1
期刊
Genetic epidemiology
卷号
37
期号
4
页码范围
393-401
简介
Characterization of genetic admixture of populations in the Americas and the Caribbean is of interest for anthropological, epidemiological, and historical reasons. Asthma has a higher prevalence and is more severe in populations with a high African component. Association of African ancestry with asthma has been demonstrated. We estimated admixture proportions of samples from six trihybrid populations of African descent and determined the relationship between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 237 ancestry informative markers in asthmatics and nonasthmatic controls from Barbados (190/277), Jamaica (177/529), Brazil (40/220), Colombia (508/625), African Americans from New York (207/171), and African Americans from Baltimore/Washington, D.C. (625/757). We estimated individual ancestries and evaluated genetic stratification using Structure and principal …
学术搜索中的文章
C Vergara, T Murray, N Rafaels, R Lewis, M Campbell… - Genetic epidemiology, 2013