作者
Caitlin E O’brien, Tony Wyss-Coray
发表日期
2014/6
来源
Journal of Neuroimmune Pharmacology
卷号
9
页码范围
285-292
出版商
Springer US
简介
Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer’s Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease.
学术搜索中的文章
CE O'brien, T Wyss-Coray - Journal of Neuroimmune Pharmacology, 2014