作者
Stephen M Collins, Zain Kassam, Premysl Bercik
发表日期
2013/6/1
来源
Current opinion in microbiology
卷号
16
期号
3
页码范围
240-245
出版商
Elsevier Current Trends
简介
Highlights
- Behavioral phenotype can be transferred via the intestinal microbiota in mice.
- Changes in behavior in recipient mice are accompanied by changes in brain chemistry.
- Investigation of the intestinal microbiome in central nervous system (CNS) disorders is warranted.
- Donor screening for fecal transplants should exclude CNS and psychiatric illness.
- Intestinal commensal bacteria or their products may be used to treat CNS disorders.
There is growing interest in the ability of the intestinal microbiome to influence host function within and beyond the gastrointestinal tract. Here we review evidence of microbiome–brain interactions in mice and focus on the ability to transfer behavioral traits between mouse strains using fecal microbiota transplantation (FMT). Transplantation alters brain chemistry and behavior in recipient ex-germ free mice, raising the possibility of using FMT for disorders of the central nervous system …
学术搜索中的文章
SM Collins, Z Kassam, P Bercik - Current opinion in microbiology, 2013