作者
Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M Starks, Claudia Emerson, Debra Hanna, Peter S Kim, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Claudia M Denkinger, Joy Fleming, Robin M Warren, Derrick Crook, James Posey, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M Engelthaler, Megan Murray, David Alland, Leen Rigouts, Christoph Lange, Keertan Dheda, Rumina Hasan, Uma Devi K Ranganathan, Ruth McNerney, Matthew Ezewudo, Daniela M Cirillo, Marco Schito, Claudio U Köser, Timothy C Rodwell
发表日期
2017/12/1
期刊
European Respiratory Journal
卷号
50
期号
6
出版商
European Respiratory Society
简介
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.
Raw genotype–phenotype correlation data were extracted as part of a comprehensive systematic review to develop a standardised analytical approach for interpreting resistance associated mutations for rifampicin, isoniazid, ofloxacin/levofloxacin, moxifloxacin, amikacin, kanamycin, capreomycin, streptomycin, ethionamide/prothionamide and pyrazinamide. Mutation frequencies in resistant and susceptible isolates were calculated, together with novel statistical measures to classify mutations as high, moderate, minimal or indeterminate confidence for predicting resistance.
We identified 286 confidence-graded mutations associated with resistance. Compared to phenotypic methods, sensitivity (95% CI) for …
学术搜索中的文章
P Miotto, B Tessema, E Tagliani, L Chindelevitch… - European Respiratory Journal, 2017