作者
Akshay Shah, Mae Chester-Jones, Susan J Dutton, Ioana R Marian, Vicki S Barber, David M Griffith, Jo Singleton, Katherine Wray, Tim James, Hal Drakesmith, Peter A Robbins, Matthew C Frise, J Duncan Young, Timothy S Walsh, Stuart R McKechnie, Simon J Stanworth, Paula Hutton, Archana Bashyal, George Chapman, Killian Donovan, Christie James, Nicola Rea, Sarah Clark, Lucy Barclay, Kate Priestley, David Hope, Corrienne McCulloch, Nicola Jacques, Shauna Bartley, Parminder Bhachu, Joanna Black, Emma Haines, Lucy Eldridge, Quentin Hill, Andrew Walden, Toby Richards
发表日期
2022/2/1
期刊
British journal of anaesthesia
卷号
128
期号
2
页码范围
272-282
出版商
Elsevier
简介
Background
Anaemia is common and associated with poor outcomes in survivors of critical illness. However, the optimal treatment strategy is unclear.
Methods
We conducted a multicentre, feasibility RCT to compare either a single dose of ferric carboxymaltose 1000 mg i.v. or usual care in patients being discharged from the ICU with moderate or severe anaemia (haemoglobin ≤100 g L−1). We collected data on feasibility (recruitment, randomisation, follow-up), biological efficacy, and clinical outcomes.
Results
Ninety-eight participants were randomly allocated (49 in each arm). The overall recruitment rate was 34% with 6.5 participants recruited on average per month. Forty-seven of 49 (96%) participants received the intervention. Patient-reported outcome measures were available for 79/93 (85%) survivors at 90 days. Intravenous iron resulted in a higher mean (standard deviation [sd]) haemoglobin at 28 days (119.8 …
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A Shah, M Chester-Jones, SJ Dutton, IR Marian… - British journal of anaesthesia, 2022