作者
Akshay Shah, Killian Donovan, Anna McHugh, Manish Pandey, Louise Aaron, Charlotte A Bradbury, Simon J Stanworth, Raza Alikhan, Stephen Von Kier, Keith Maher, Nicola Curry, Susan Shapiro, Matthew J Rowland, Matt Thomas, Richard Mason, Matthew Holland, Tom Holmes, Michael Ware, Stefan Gurney, Stuart R McKechnie
发表日期
2020/12
期刊
Critical care
卷号
24
页码范围
1-10
出版商
BioMed Central
简介
Background
Optimal prophylactic and therapeutic management of thromboembolic disease in patients with COVID-19 remains a major challenge for clinicians. The aim of this study was to define the incidence of thrombotic and haemorrhagic complications in critically ill patients with COVID-19. In addition, we sought to characterise coagulation profiles using thromboelastography and explore possible biological differences between patients with and without thrombotic complications.
Methods
We conducted a multicentre retrospective observational study evaluating all the COVID-19 patients received in four intensive care units (ICUs) of four tertiary hospitals in the UK between March 15, 2020, and May 05, 2020. Clinical characteristics, laboratory data, thromboelastography profiles and clinical outcome data were evaluated between patients with and without thrombotic complications.
Results
A total of 187 patients …
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A Shah, K Donovan, A McHugh, M Pandey, L Aaron… - Critical care, 2020