作者
Dipesh Chaudhury, Jessica J Walsh, Allyson K Friedman, Barbara Juarez, Stacy M Ku, Ja Wook Koo, Deveroux Ferguson, Hsing-Chen Tsai, Lisa Pomeranz, Daniel J Christoffel, Alexander R Nectow, Mats Ekstrand, Ana Domingos, Michelle S Mazei-Robison, Ezekiell Mouzon, Mary Kay Lobo, Rachael L Neve, Jeffrey M Friedman, Scott J Russo, Karl Deisseroth, Eric J Nestler, Ming-Hu Han
发表日期
2013/1/24
期刊
Nature
卷号
493
期号
7433
页码范围
532-536
出版商
Nature Publishing Group UK
简介
Ventral tegmental area (VTA) dopamine neurons in the brain’s reward circuit have a crucial role in mediating stress responses,,,, including determining susceptibility versus resilience to social-stress-induced behavioural abnormalities. VTA dopamine neurons show two in vivo patterns of firing: low frequency tonic firing and high frequency phasic firing,,. Phasic firing of the neurons, which is well known to encode reward signals,,, is upregulated by repeated social-defeat stress, a highly validated mouse model of depression,,,,,. Surprisingly, this pathophysiological effect is seen in susceptible mice only, with no apparent change in firing rate in resilient individuals,. However, direct evidence—in real time—linking dopamine neuron phasic firing in promoting the susceptible (depression-like) phenotype is lacking. Here we took advantage of the temporal precision and cell-type and projection-pathway specificity of …
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D Chaudhury, JJ Walsh, AK Friedman, B Juarez… - Nature, 2013