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Human papillomavirus (HPV) is one of the causes of cervical cancer in women. These viruses have DNA-type genetic material, are not enveloped, and are divided into two types based on their ability to trigger cancer. High-risk HPV is the type of HPV that often causes cervical cancer cases, this is due to the high expression of oncoprotein E6. E6 works through the inhibition and degradation of p53 to trigger cancer. HPV drugs tend to be expensive and must use alternative solutions such as the herbal Curcuma longa L. Curcuma longa L. is an herbal plant that is widely used by the public for their daily needs, for example as an antiviral, antioxidant, and anti-inflammatory. This study aims to predict the molecular mechanism and screening of drug candidate compounds in Curcuma longa L. to inhibit the activity of the HPV E6 protein through a bioinformatics approach. This study used in silico methods such as docking …