作者
Joana M Xavier, Farhad Shahram, Fereydoun Davatchi, Alexandra Rosa, Jorge Crespo, Bahar Sadeghi Abdollahi, Abdolhadi Nadji, Gorete Jesus, Filipe Barcelos, José Vaz Patto, Niloofar Mojarad Shafiee, Fahmida Ghaderibarim, Sofia A Oliveira
发表日期
2012/8
期刊
Arthritis & Rheumatism
卷号
64
期号
8
页码范围
2761-2772
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Independent replication of the findings from genome‐wide association studies (GWAS) remains the gold standard for results validation. Our aim was to test the association of Behçet's disease (BD) with the interleukin‐10 gene (IL10) and the IL‐23 receptor–IL‐12 receptor β2 (IL23R–IL12RB2) locus, each of which has been previously identified as a risk factor for BD in 2 different GWAS.
Methods
Six haplotype‐tagging single‐nucleotide polymorphisms (SNPs) in IL10 and 42 in IL23R–IL12RB2 were genotyped in 973 Iranian patients with BD and 637 non‐BD controls. Population stratification was assessed using a panel of 86 ancestry‐informative markers.
Results
Subtle evidence of population stratification was found in our data set. In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95 …
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JM Xavier, F Shahram, F Davatchi, A Rosa, J Crespo… - Arthritis & Rheumatism, 2012