作者
Mário Luciano de Mélo Silva Júnior, Lívia Maria Alves de Souza, Renata Ellen Maria Carvalho Dutra, Ramon Goncalves de Melo Valente, Thayanara Silva Melo
发表日期
2021/6
来源
Postgraduate Medical Journal
卷号
97
期号
1148
页码范围
391-398
出版商
Oxford University Press
简介
Introduction
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been caused the greatest pandemic of our century. Many of the deaths related to it are due to a systemic inflammatory response, which has been called ‘cytokine storm’.
Objectives
We developed a comprehensive review of the pathophysiology mechanisms of COVID-19 and of the rationale for drugs and therapeutics that have been tested in clinical trials.
Methods
A narrative review of the literature was conducted using PubMed, SciELO, Bireme, Google Scholar and ClinicalTrials.
Results
SARS-CoV-2 has evolutive mechanisms that made it spread all around the globe, as a higher latency period and a lesser lethality than other coronaviruses. SARS-CoV-2 causes a delay in the innate immune response and it disarranges the immune system leading to an …
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ML de Mélo Silva Júnior, LMA de Souza, REMC Dutra… - Postgraduate Medical Journal, 2021