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Machine-part interaction classification is a key capability required by Cyber-Physical Systems (CPS), a pivotal enabler of Smart Manufacturing (SM). While previous relevant studies on the subject have primarily focused on time series classification, change point detection is equally important because it provides temporal information on changes in behavior of the machine. In this work, we address point detection and time series classification for machine-part interactions with a deep Convolutional Neural Network (CNN) based framework. The CNN in this framework utilizes a two-stage encoder-classifier structure for efficient feature representation and convenient deployment customization for CPS. Though data-driven, the design and optimization of the framework are Subject Matter Expertise (SME) guided. An SME defined Finite State Machine (FSM) is incorporated into the framework to prohibit intermittent …