作者
Mahmoud M Abouelfetouh, Eman Salah, Mingxing Ding, Yi Ding
发表日期
2021/7
来源
Journal of Veterinary Pharmacology and Therapeutics
卷号
44
期号
4
页码范围
478-502
简介
Alpha2‐adrenergic agonists have been implicated in the development of pulmonary edema (PE) and sustained hypoxemia that lead to life‐threatening pulmonary distress in ruminants, especially with sensitive and compromised animals. Recently, there is limited understanding of exact mechanism underlying pulmonary alterations associated with α2‐adrenergic agonist administration. Ruminants have a rich population of pulmonary intravascular macrophages (PIMs) in the pulmonary circulation, which may be involved in the development of pulmonary alveolo‐capillary barrier damage. Hence, the central thesis of this review is overviewing the literatures regarding the systemic use of α2‐adrenergic agonists in domestic ruminants, focusing on their pulmonary side effects, especially on the influence of PIMs on the lung. At this moment, further studies are needed to provide a clear emphasis and better understanding …
引用总数
20212022202320243412