作者
Dong Il Park, Mun Su Kang, Suk Joong Oh, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Won Kon Han, Hungdai Kim, Seung Ho Ryu, Antonia R Sepulveda
发表日期
2007/5
期刊
International journal of colorectal disease
卷号
22
页码范围
491-497
出版商
Springer-Verlag
简介
Background and aims
The HER-2/neu protein is intimately involved with normal cell proliferation and tissue growth, as it is extensively homologous and is related to the epidermal growth factor receptor. This phenomenon has been most intensively studied in the context of breast carcinoma, in which its amplification and overexpression correlate with the overall course of disease and poor prognoses, and also constitute a predictive factor of poor response to chemotherapy and endocrine therapy. In this study, we investigated the relationships between the expression of HER-2/neu and the clinicopathological characteristics of colorectal cancer, including survival. This study was performed with a view toward the future introduction of Herceptin therapy for colorectal cancer patients.
Patients and methods
HER-2/neu overexpression and gene …
引用总数
学术搜索中的文章
DI Park, MS Kang, SJ Oh, HJ Kim, YK Cho, CI Sohn… - International journal of colorectal disease, 2007