作者
Michael J Lipinski, Giuseppe GL Biondi-Zoccai, Antonio Abbate, Reena Khianey, Imad Sheiban, Jozef Bartunek, Marc Vanderheyden, Hyo-Soo Kim, Hyun-Jae Kang, Bodo E Strauer, George W Vetrovec
发表日期
2007/10/30
期刊
Journal of the American College of Cardiology
卷号
50
期号
18
页码范围
1761-1767
出版商
Journal of the American College of Cardiology
简介
Objectives
We aimed to perform a meta-analysis of clinical trials on intracoronary cell therapy after acute myocardial infarction (AMI).
Background
Intracoronary cell therapy continues to be evaluated in the setting of AMI with variable impact on left ventricular ejection fraction (LVEF).
Methods
We searched the CENTRAL, mRCT, and PubMed databases for controlled trials reporting on intracoronary cell therapy performed in patients with a recent AMI (≤14 days), revascularized percutaneously, with follow-up of ≥3 months. The primary end point was change in LVEF, and secondary end points were changes in infarct size, cardiac dimensions, and dichotomous clinical outcomes.
Results
Ten studies were retrieved (698 patients, median follow-up 6 months), and pooling was performed with random effect. Subjects that received intracoronary cell therapy had a significant improvement in LVEF (3.0% increase [95 …
引用总数
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MJ Lipinski, GGL Biondi-Zoccai, A Abbate, R Khianey… - Journal of the American College of Cardiology, 2007