作者
Joo-Yong Hahn, Hyun-Ju Cho, Hyun-Jae Kang, Tack-Seung Kim, Mi-Hyung Kim, Jung-Hwa Chung, Jang-Whan Bae, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim
发表日期
2008/3/4
期刊
Journal of the American College of Cardiology
卷号
51
期号
9
页码范围
933-943
出版商
Journal of the American College of Cardiology
简介
Objectives
The goal of this study was to investigate the effect of pre-treatment of mesenchymal stem cells (MSCs) with growth factors (GFs) on cardiomyogenic differentiation, cytoprotective action on cardiomyocytes (CMCs), and their therapeutic efficacy in myocardial infarction.
Background
Mechanisms of myocardial repair with MSC transplantation have not been fully elucidated, and therapeutic efficacy needs to be enhanced.
Methods
The MSCs obtained from the bone marrow of Fisher344 rats were treated with fibroblast growth factor-2, insulin-like growth factor-1, and bone morphogenetic protein-2. The expression of cardiac specific markers and the cytoprotective effect of MSCs with its mechanism were evaluated. Efficacy of MSCs transplantation was studied in rat myocardial infarction model.
Results
Treatment of MSCs with cocktails of GFs enhanced expression of cardiac transcription factors and survival …
引用总数
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JY Hahn, HJ Cho, HJ Kang, TS Kim, MH Kim… - Journal of the American College of Cardiology, 2008