查看文章

Adult stem cell therapy is expected to improve left ventricular function in patients with myocardial infarction. Because of the low risk of arrhythmia and the maximal concentration at the target tissue, intracoronary infusion of stem cells is preferred. The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with ¹⁸F-FDG. Seventeen patients with myocardial infarction were included as the intracoronary injection group (14 males, 3 females; age, 58 ± 12 y). Three patients underwent intravenous stem cell injection as the intravenous injection group (3 males, 0 females; age, 50 ± 20 y). After mobilization with granulocyte colony-stimulating factor (G-CSF), peripheral stem cells were collected by means of apheresis. ¹⁸F-FDG labeling of stem cells was performed for 40 min with gentle intermittent mixing at 37°C. The mean labeling …