作者
Amirali Popat, Benjamin P Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao
发表日期
2012/11/5
期刊
Angewandte Chemie (International ed. in English)
卷号
51
期号
50
页码范围
12486-12489
简介
I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.
学术搜索中的文章
A Popat, BP Ross, J Liu, S Jambhrunkar, F Kleitz… - Angewandte Chemie (International ed. in English), 2012