作者
Peilin Jia, Xiangning Chen, Wei Xie, Kenneth S Kendler, Zhongming Zhao
发表日期
2019/4/25
期刊
Schizophrenia Bulletin
卷号
45
期号
3
页码范围
698-708
出版商
Oxford University Press
简介
Numerous high-throughput omics studies have been conducted in schizophrenia, providing an accumulated catalog of susceptible variants and genes. The results from these studies, however, are highly heterogeneous. The variants and genes nominated by different omics studies often have limited overlap with each other. There is thus a pressing need for integrative analysis to unify the different types of data and provide a convergent view of schizophrenia candidate genes (SZgenes). In this study, we collected a comprehensive, multidimensional dataset, including 7819 brain-expressed genes. The data hosted genome-wide association evidence in genetics (eg, genotyping data, copy number variations, de novo mutations), epigenetics, transcriptomics, and literature mining. We developed a method named mega-analysis of odds ratio (MegaOR) to prioritize SZgenes. Application of MegaOR in the …
引用总数
20182019202020213333