作者
Yuhui Du, Godfrey D Pearlson, Qingbao Yu, Hao He, Dongdong Lin, Jing Sui, Lei Wu, Vince D Calhoun
发表日期
2016/1/1
期刊
Schizophrenia research
卷号
170
期号
1
页码范围
55-65
出版商
Elsevier
简介
Default mode network (DMN) has been reported altered in schizophrenia (SZ) using static connectivity analysis. However, the studies on dynamic characteristics of DMN in SZ are still limited. In this work, we compare dynamic connectivity within DMN between 82 healthy controls (HC) and 82 SZ patients using resting-state fMRI. Firstly, dynamic DMN was computed using a sliding time window method for each subject. Then, the overall connectivity strengths were compared between two groups. Furthermore, we estimated functional connectivity states using K-means clustering, and then investigated group differences with respect to the connectivity strengths in states, the dwell time in each state, and the transition times between states. Finally, graph metrics of time-varying connectivity patterns and connectivity states were assessed. Results suggest that measured by the overall connectivity, HC showed stronger inter …
引用总数
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